This study was attempted to confirm the correlation between anxiety, communication skills, and nursing professionalism due to the replacement on-campus practice of nursing students due to the COVID-19 outbreak. The subjects of this study were 131 nursing students in 3rd and 4th grade, and data were collected from October 30, 2021 to November 23, 2021. The collected data were analyzed with SPSS Statistics 28.0 using descriptive statistics, t-test, ANOVA, and Person’s correlation. As a result of the study, it was found that there was a negative correlation between anxiety and nursing professionalism(r=-.332, p <.001), and there was a positive correlation between communication ability and nursing professionalism (r=.364, p =.000) Based on this study, it is necessary to develop and apply an effective clinical practice education intervention method that can reduce anxiety caused by on-campus practice to enhance nursing professionalism and enhance communication ability. Based on this study, it is necessary to understand the relationship between grade level and nursing professionalism, and to develop and apply an effective anxiety intervention method that can increase nursing professionalism by reducing anxiety caused by on-campus practice.