This study was intended to demonstrate the effect of the smart factory process operation strategy of the chief technology executive of a manufacturing company on the manufacturing cost. As a sampling method for this study, a questionnaire sample was extracted by the judgment sampling method, and the survey was conducted focusing on manufacturing companies. The survey period was conducted from June 7 to 24, 2020. The first 189 copies were distributed and 187 copies were recovered. In addition, 178 copies were used as analysis data for this study, except for 9 questionnaires that were distinguished by systematic or non-systematic errors. After that, it went through the data coding process and was tested using SPSS and AMOS programs. As a result of the study, the hypothesis that the CEO's smart factory process operation strategy affects manufacturing cost was partially adopted. As for the detailed results, first, the smart factory process operation strategy had a statistically significant relationship with the overall facility efficiency, and the smart factory process operation strategy showed a statistically insignificant result on the manufacturing cost. On the other hand, it was verified that the total facility efficiency represents a statistically significant value for the manufacturing cost.