The U.S. is currently at a fierce war with fentanyl, which is called the "devil's drug" or "zombie drug." Over the seven years from 2015 to the present, the death toll from fentanyl overdoses is approaching 210,000. Fentanyl is a painkiller designed for terminal cancer patients or people complaining of extreme pain, and the lethal dose of fentanyl is only 2 mg. The U.S. Drug Enforcement Administration (DEA) is preparing active countermeasures against fentanyl, labeling it the "lethal drug facing the United States," and the U.S. FDA and the Office of Drug Abuse and Mental Health Services (SAMHSA) are striving for treatment and rehabilitation by announcing in a joint statement a plan to provide evidence-based treatment for opioid use disorder (OUD). To this end, while suggesting SAHMSA's 2023-2026 strategic plan, the contents related to double drug addiction are included in the field of drug overdose prevention, which is the first priority. To this end, the government is preparing continuous treatment and recovery approaches with the greatest emphasis on securing the budget. This movement in the United States teaches a number of lessons about our fentanyl crisis. Based on the problems of fentanyl misuse, abuse, and prescription, Korea has also prepared comprehensive measures for the management of new drugs such as fentanyl since last year, and is discussing countermeasures at the government level. Basically, while detecting and cracking down on drug offenders, they help treat addicts through drug addiction rehabilitation education during the same period, and compulsory education such as drug prevention, including drugs, is being conducted in all elementary, middle, and special schools to prevent drug addiction in adolescents. In response, this study proposed a plan to control new drugs such as fentanyl through a combination of treatment-oriented countermeasures of SAHMSA in the United States and our judicial crackdown, identified the distribution and management flow of fentanyl, established comprehensive measures, and presented pan-government drug management measures by subdividing them into inflow monitoring, distribution control, judicial processing, treatment and rehabilitation, and education and public relations.