This study analyzes the effects of the depth and breadth of entrepreneurship education on entrepreneurship of university start-up club members by considering self-efficacy as a moderating variable. Based on 657 questionnaires collected from 12 universities in North and South Jeolla Province, the results of this study were as follows. First, the depth of entrepreneurship education has been shown to have a significant impact on proactiveness and innovativeness. Second, the breadth of entrepreneurship education was shown to have a significant positive impact on both risk-taking propensities, proactiveness and innovativeness. Third, an analysis of the moderating effect of self-efficiency shows that self-efficiency positively moderates not only the relationship between depth of entrepreneurship education and proactiveness, but also the relationship between depth of entrepreneurship education and innovativeness. This study could provide meaningful implications for the field of entrepreneurship education in that it divides entrepreneurship education into depth and breadth, it identifies the relationship between entrepreneurship education and entrepreneurship of university start-up club members, and provides evidence. Also, this study has a practical implication for the field of entrepreneurship education in that it shows different moderating effect of self-efficacy in the relationship between entrepreneurship education and entrepreneurship of university start-up club members.