Daegu and Gyeongbuk go through the largest number of confirmed cases at the early stages of the spread of COVID-19. Therefore this study measures the damage of COVID-19 in the Daegu-Gyeongbuk tourist area and analyzes the ripple effect. Using credit card data, we calculated the decrease in tourismsales, and that was tallied at 64.4 billion. themost of the negative impact is concentrated in the food and bar sector. As a result of the input-output analysis, the decrease ripple effect in production is 146.3 billion, and the number of employe decreased by 1,355 people. The indirect negative effects is concentrated in Seoul, Gyeonggi, and Gyeongnam, excluding Daegu and Gyeongbuk, and froman industrial point of view, it tends to be concentrated inmanufacturing and agriculture, forestry and fisheries sectors, excluding tourism sectors. This study presents the point for tourismpolicies tailored to the region-industry structure through the impact of COVID-19 and ripple effect path through regions and industries.