The purpose of this study is to identify anxiety and depression level for corona virus 19 among hospital nurses to the spread of COVID-19. Data were collected from 232 nurses in 5 hospitals from August to September in 2020 using questionnaire. Characteristics relative to variables were measured, and analyzed using SPSS 26.0 program for descriptive statistics, t-test, ANOVA, and pearson’s correlation. The depression level differed according to gender. The anxiety about COVID-19 infection showed a significantly positive correlation to depression (r=.26, p<.001). Based on these results, several roles and coping strategies were suggested to help nurses recover and maintain their psychological stability and mental health.