The purpose of this study is to understand the mediating effect of self-leadership in the process of understanding the effects of nursing job performance and job satisfaction in the nursing work environment perceived by nurses. In this study, nurses who worked for more than one year at three general hospitals located in Province A. Total of 225 data were used for the final analysis. Date analyzed using the SPSS 22.0 program by t-test, ANOVA, Pearson's correlation coefficient and hierarchical regression analysis. Self-leadership was found to play a partial mediating role in the relationship between nursing work environment and nursing job performance(z=4.30, p <.001) and between nursing work environment and job satisfaction(z=3.70, p <.001). Therefore, in order to improve nursing job performance and job satisfaction, it will be necessary to establish a management plan that can improve the nursing work environment and improve self-leadership.