This study investigated the effects of the maker education program science class applying the TMSI model on elementary school students’ academic achievement in science and scientific attitudes. This study involved 40 sixth-grade students from an elementary school in a metropolitan city, classified into an experimental group and a comparison group. The experimental group participated in the maker education program class applying the TMSI Model, whereas the control group experienced a traditional teacher-centered class as outlined in the teachers’ guidebook. The results of the study were as follows. First, the maker education program science class applying the TMSI model had a significant effect on improving students’ academic achievement in science. Second, the maker education program science class applying the TMSI model had a significant effect on improving students’ science-related attitudes. Based on these results, the implications for science education and future research directions related to the application of maker education to science were discussed.