Optimization of physicochemical properties of pyrrolidine GPR40 AgoPAMs results in a differentiated profile with improved pharmacokinetics and reduced off-target activities
Resource Type
Article
Authors
Jurica, Elizabeth A. ; Wu, Ximao ; Williams, Kristin N. ; Haque, Lauren E. ; Rampulla, Richard A. ; Mathur, Arvind ; Zhou, Min ; Cao, Gary ; Cai, Hong ; Wang, Tao ; Liu, Heng ; Xu, Carrie ; Kunselman, Lori K. ; Antrilli, Thomas M. ; Hicks, Michael B. ; Sun, Qin ; Dierks, Elizabeth A. ; Apedo, Atsu ; Moore, Douglas B. ; Foster, Kimberly A. ; Cvijic, Mary Ellen ; Panemangalore, Reshma ; Khandelwal, Purnima ; Wilkes, Jason J. ; Zinker, Bradley A. ; Robertson, Donald G. ; Janovitz, Evan B. ; Galella, Michael ; Li, Yi-Xin ; Li, Julia ; Ramar, Thangeswaran ; Jalagam, Prasada Rao ; Jayaram, Ramya ; Whaley, Jean M. ; Barrish, Joel C. ; Robl, Jeffrey A. ; Ewing, William R. ; Ellsworth, Bruce A.
Source
In Bioorganic & Medicinal Chemistry 1 May 2023 85
Subject
Language
ISSN
0968-0896