A versatile fast-development platform applied to closed-loop diaphragmatic pacing
- Resource Type
- Conference
- Authors
- Zbrzeski, A.M.; Siu, R.; Bornat, Y.; Hillen, B.K.; Jung, R.; Renaud, S.
- Source
- 2015 7th International IEEE/EMBS Conference on Neural Engineering (NER) Neural Engineering (NER), 2015 7th International IEEE/EMBS Conference on. :791-794 Apr, 2015
- Subject
- Aerospace
Rodents
Electrodes
Spinal cord injury
Hardware
Real-time systems
Delays
Adaptation models
- Language
- ISSN
- 1948-3546
1948-3554
People with cervical spinal cord injury have partial or complete loss of ventilatory control and require ventilator assist. Open-loop diaphragmatic pacing can be utilized to provide this assist. A closed-loop diaphragmatic pacing system could overcome the drawbacks for manual titration of the stimulation and respond to changing ventilatory requirements. We have developed a versatile custom hardware platform dubbed “Multimed” for biosignal acquisition and parallel real-time computation, data display and storage. We have also developed a new rodent model for diaphragmatic pacing. Using these we illustrate, to our knowledge for the first-time, the successful ability to perform respiratory flow-phase triggered closed-loop diaphragmatic stimulation with resultant changes in respiratory flow and tidal volume.