The CHRONIOUS system addresses a smart wearable platform, based on multi-parametric sensor data processing, for monitoring people suffering from chronic diseases in long-stay setting. Several signals are being recorded through wearable sensors and are stored together with additional information, entered by the patient. An Intelligent System, placed at a Smart Assistant Device, analyzes incoming data and facilitates data mining techniques resulting upon the severity of a health episode. Part of the Intelligent System is the Mental Support Tool, which calculates a Stress Index and classifies the mental condition and stress levels of the patient. An additional component aiming at the personalization of the Intelligent System's Decision is the Profiler which defines several patients profiles and facilitates clustering techniques in order to associate each patient's description with one of the predefined profiles.