Pharmaceutical drugs are essential in diagnosing and treating patients. However, over the past decade, the issue of fraud and abuse drugs in the pharmaceutical supply chain has become increasingly apparent. To solve these problems, a transformation of the current pharmaceutical supply chain to include tracking technologies, from the source of the ingredients to the consumer, is recommended. In this paper, we investigate the novel pharmaceutical governance based on IoT and Blockchain technology. Internet of Things (IoT) based blockchain is a type of distributed ledger (DLT) that maintains an immutable record of all transaction information that is incapable of being falsified and is visible to all participants. Implementing an IoT-based blockchain system would provide the tools for the pharmaceutical industry to improve drug governance along the supply chain, thus making healthcare more efficient and reliable.