Diffractometric biochemical sensing with smart hydrogels
- Resource Type
- Conference
- Authors
- Chang, Chun-Li; Ding, Zhenwen; Patchigolla, Venkata N. L. R.; Ziaie, Babak; Savran, Cagri A.
- Source
- 2010 IEEE Sensors Sensors, 2010 IEEE. :1617-1621 Nov, 2010
- Subject
- Photonics and Electrooptics
Communication, Networking and Broadcast Technologies
Computing and Processing
Components, Circuits, Devices and Systems
Diffraction
Diffraction gratings
Gratings
Measurement by laser beam
Sensor phenomena and characterization
Gold
- Language
- ISSN
- 1930-0395
We report reflective diffraction gratings made from smart hydrogels for ultrasensitive biochemical detection. As an example for a biochemically responsive hydrogel, we chose a pH-sensitive hydrogel to construct diffraction gratings that swell or shrink due to changes in pH. Interferometric analysis of the grating enabled detection of the hydrogel's swelling/shrinking with nanoscale precision with a resolution of 6×10 −4 pH units. The developed system is remarkably simple both to fabricate and operate. Moreover, the concept of the hydrogel grating is generic and can be widely applied to hydrogels responsive to other stimuli.