Based on the method of mathematical model, the sensitivity relationship between the cyclic wave load and the influencing factors such as wave height, period and water depth is simulated under the environment of clear water and muddy water mixture. Combined with the results of physical model test, the variation law of wave force in different environment is further analyzed. At the same time, according to the stress results, aiming at the applicability of the actual water intake and drainage engineering pipeline in the construction and operation, the reinforcement measures are proposed. The research results can provide basic data and technical guidance for the engineering design and lying of the pipeline.