Interest is an important concept in the field of psychology and pedagogy. At present, the scope of research is very extensive, but there is little research on the relationship between interests. This research adopts the theory and method of big data association and cluster analysis. The relationship between interest and interest is excavated. It is found that there are a large number of association and clustering relationships among human interests, and some association rules have high degree of confidence, promotion and support. This shows that there are certain internal relations between human interests and hobbies. The research results can be used in other areas of interest, such as interest cultivation, etc.