In order to study seismic responses of high-pier continuous rigid frame bridge under seismic waves of oblique incidence and under Topographic effect, this paper built a finite element model of 6-span continuous rigid frame bridge in concave valley terrain by use of the finite element software ABAQUS, and analyzed the seismic responses of a bridge under the circumstances of seismic waves of different incident angles, different bridge pier sizes and different stiffness by use of that model. The results indicate that the internal forces of structure change with the change in the incident angles of seismic wave; due to the existence of local topography, the local internal forces of bridge structure magnify; when piers have an identical cross-section area, a solid pier can more effectively reduce the pier stress, compared with a hollow pier; in the case of an identical cross-section size and identical longitudinal stiffness, a hollow pier can more effectively reduce the pier stress; the larger the number of straining beams that a pier has is, the larger the stiffness is, and the worse it is for the seismic resistance of bridge.