A deep understanding of the existing problems in the traditional engineering specialty plays a curial role in building the new engineering curriculum. The achievement orientation, curriculum crossover, and content connection induce the lack of practical, innovative, and forward-looking in traditional engineering, which weakens the high-quality development of engineering students. Here, we propose a new engineering curriculum based on a multi-disciplinary and cross-integration system, meeting the development requirement of the engineering ability and scientific-technological innovation. We adopt the multi-integration training mode, collaborating with multi-resources of government-user-industry-university-research and cross-collaborating with multi-disciplinary of science-engineering-literature-management-law-medicine. The new curriculum system promotes students' comprehensive ability on the petrochemical emergency foundation, engineering practice, engineering innovation, and multi-innovation, fulfilling the theoretical, practical, engineering, and innovation cultivation requirements, respectively. We apply this curriculum system to cultivate under-graduates of petrochemical emergency engineering disciplines, improving their comprehensive ability significantly. The results may reference the new engineering education reform and associated curriculum system construction.