Detection of copy number variation using scale space filtering
- Resource Type
- Conference
- Authors
- Lee, Jongkeun; Kim, Baeksop; Yoon, Jeehee; Lee, Unjoo
- Source
- 2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society Engineering in Medicine and Biology Society, EMBC, 2011 Annual International Conference of the IEEE. :5555-5558 Aug, 2011
- Subject
- Bioengineering
Communication, Networking and Broadcast Technologies
Components, Circuits, Devices and Systems
Computing and Processing
Signal Processing and Analysis
Humans
Genomics
Error analysis
Filtering
Bioinformatics
Databases
Convolution
- Language
- ISSN
- 1557-170X
1094-687X
1558-4615
This study proposes a novel CNV detection algorithm based on scale space filtering. It uses Gaussian filter for the convolution with a scale parameter. The range of the scale parameter is adjusted according to the coverage level of read data. The position of a CNV region is determined through a coarse and a fine searches over the scales. The results showed low dependency of the performance of the proposed method on the coverage level compared to the conventional methods. The results also showed that the proposed method outperforms the conventional methods by 63.29 ∼ 73.57 %.