This volume contains a broad collection of research of both foundational and applied type, written by both well-known groups of experts and young researchers. In these papers different theories, algorithms, data driven approaches and formalisms have been applied to modeling of different aspects of intelligent applications. It contains 27 sessions in 18 streams. Ten of the sessions are invited ones and 2 are poster sessions in various fields. This volume constitutes the proceedings of IS′16 - The 2016 IEEE International Conference on Intelligent Systems held on September 4–6, 2016 in Sofia, Bulgaria. The IS'16 is the eighth conference in the well known and highly respected line of conferences in this series which have been biannually organized since 2002, across EU, in Bulgaria, Poland and the United Kingdom.