The surface transmission of the virus can be divided into direct transmission and indirect transmission. With the outbreak of the COVID-19 epidemic, there is an urgent need for an antiviral surface that can effectively reduce surface contact transmission. In our work, a simple and efficient antiviral surface of copper nanoparticles was prepared by laser direct writing, which can effectively kill the virus, and the antiviral mechanism of Cu nanoparticles was discussed. The results indicate that the surface of the copper nanoparticles we prepared has efficient and good antiviral properties, which can effectively inactivate viruses in a short period of time, providing a way to prevent the spread of viruses through contact.