Defense-intrusion games are fascinating in both nature and the artificial world. In these games, the purpose of defender is to protect the target from being attacked by the intruder, and if possible, capture the intruder. This article solves the defense-intrusion game with considering the bio-inspired model adopted by two agents-a defender and an intruder, and obtains the attack and interception strategies. The intruder usually need to avoid the defender, so we provide attack strategy based on setting the intruder's emergency maneuver distance, and compare it with the strategy based on artificial potential field method proposed in our previous work. For the defender, we design a radical interception strategy and a conservative interception strategy according to different circumstances. Numerical simulations are conducted to illustrate the effectiveness of the proposed strategies. The results are consistent with natural observations and disclose some natural laws in the defense-intrusion scenario. This paper will provide a reference for the research of intrusion prevention related to marine robots.