The Transportation Cybersecurity Center for Advanced Research and Education (CYBER-CARE) is a US Department of Transportation (USDOT) Tier-1 University Transportation Center (UTC) funded in 2023. CYBER-CARE primarily focuses on the USDOT statutory research priority area of “Reducing Transportation Cybersecurity Risks.” CYBER-CARE aims to establish a fundamental knowledge basis and explore advanced theory to mitigate the impacts of large-scale cyberattacks on transportation infrastructure and connected and automated vehicle (CAV) systems. The research projects at CYBER-CARE will develop conceptual frameworks, construct comprehensive datasets, explore novel analytical approaches, support the implementation of public policies and infrastructure investments, and build a high-quality industry workforce through education. All CYBER-CARE research projects can be organized into four thrusts: CAV cybersecurity, transportation data security, advanced traffic management system (ATMS) cybersecurity, and next-generation transportation cybersecurity systems. In addition, CYBER-CARE will accelerate industry collaborations, foster new technologies, and provide professionals with the skills and opportunities needed to become successful leaders in their fields. Notably, as CYBER-CARE will prioritize engagement with underrepresented minorities, these communities stand to benefit from professional development training in transportation cybersecurity.