In this work, SrO buffer layers were employed as an interface engineering approach to realize single crystalline mixed ternary rare earth bixbyite oxide (RE 2 O 3 ) films on Si (001) substrate. Single crystalline mixed Pr x Y 2−x O 3 (x=0–2) has been successfully grown on Si (111) (Ref. 7). However, the formation of such mixed oxide can only be realized at >750 °C, therefore when it is directly grown on Si (001) Pr x Y 2−x O 3 is polycrystalline due to the formation of an amorphous silicate or SiO 2 interfacial layer on Si (001). A 1/2 monolayer (ML) SrO buffer layer can effectively prevent the interface reaction thus it allows realizing single crystalline ternary mixed Pr 0.9 Y 1.1 O 3 films on Si (001). This fully lattice-matched RE 2 O 3 film demonstrates 110 orientation on Si (001). Furthermore, SrO buffer layers are not only important to control the single crystallinity but also the growth orientation and crystallization behaviour of ternary RE 2 O 3 films. A 111-oriented, phase separated Pr 2 O 3 -Y 2 O 3 film was obtained under identical growth conditions by simply increasing the thickness of SrO buffer layer to 3 ML.