Electrical propagation patterns in a 3D regionally ischemic human heart: A simulation study
- Resource Type
- Conference
- Authors
- Heidenreich, EA; Rodriguez, JF; Doblare, M; Trenor, B; Ferrero, JM
- Source
- 2009 36th Annual Computers in Cardiology Conference (CinC) Computers in Cardiology, 2009. :665-668 Sep, 2009
- Subject
- Bioengineering
Communication, Networking and Broadcast Technologies
Components, Circuits, Devices and Systems
Computing and Processing
Signal Processing and Analysis
Robotics and Control Systems
General Topics for Engineers
Humans
Heart
- Language
- ISSN
- 0276-6574
2325-8853
In this work, we have studied the different propagation patterns displayed in a human heart during acute ischemia. A 3-D geometrically and anatomically accurate regionally ischemic human heart was simulated. The ischemic region was located in the anterior side of the left ventricle mimicking the occlusion of the circumflex artery. Realistic heterogeneity and fiber anisotropy has been considered in the model. The electrical activity of each cell was reproduced using a modified version of the ten Tusscher 2006 action potential model. The model predicts the generation of figure-of-eight re-entries which cross the central ischemic zone formed in the epicardial surface due to the longer refractory period of the midmyocardial layers. Also, focal activity experimentally observed in the epicardium could be caused by re-entrant wavefronts propagating in the mid-myocardium that reemerge in the heart surface.