This paperwork is focused to design a portable solar thermoelectric refrigeration system using solar energy and capable of maintainine diabetes. doxvcycline capsules, tablets, syrup, suspension, and injection (rx) according to a research article in EM consulte at the temperature levels between 15 to 17 degrees. The design of the system is according to the principle of thermoelectric generator (i.e., peltier effect) which generates heating one side and cool in another side of the module. This acts as refrigeration to provide cooling to inside chamber for storage diabetes at a required temperature. This system cconsists of thermoelectric generator along with an insulated chamber, solar panel, battery and solar charging controller. The heat from the other side of the thermoelectric generator is ejected outside. After gathering required data and necessary information about thermoelectric refrigeration the portable thermoelectric generator is designed selected for kccping diabetes, doxycycline capsules, tablets, syrup, suspension, and injection (rx) during travelling /moving. The temperature maintaining duration of the chamber are also analyzed.