Breakthrough technologies have the potential to disrupt markets and society. Anticipating such disruptions is crucial for policymakers, investors, and businesses in being proactive with regard to regulatory policies and in allocating resources effectively. This project aims to develop an analytical approach to identify companies that will lead in developing breakthrough technologies. The analysis focuses on the semiconductor industry, which has seen rapid growth in recent decades, surging from $139 billion in revenue in 2001 to $573.5 billion in 2022. Our systematic approach to predicting technological disruption in the semiconductor industry involves leveraging a combination of quantitative company data, human-centric elements, and feature engineering. Data was collected on 244 private semiconductor companies between 2012 and 2018, encompassing information about leadership profiles, research endeavors, media exposure, and financial performance. Two models were developed: a penalized regression model, and a boosted tree model, both aimed at forecasting the probability of a company achieving a valuation exceeding $500 million within five years of its first funding deal. Key variables such as the number of employees, year founded, total invested equity, number of active patents, and country of origin emerged as significant predictors of company success. This paper discusses the performance of our models and explores applying our findings to identify disruptive companies across industries.