Microwave flow chemistry: Single-mode system for kg-scale organic synthesis
- Resource Type
- Conference
- Authors
- Sato, Kohei; Ueda, Jun; Kon, Takuya; Nakamura, Yushi; Fujimoto, Junko; Narumi, Tetsuo; Takeda, Kazuhiro; Mase, Nobuyuki
- Source
- 2022 Asia-Pacific Microwave Conference (APMC) Microwave Conference (APMC), 2022 Asia-Pacific. :169-171 Nov, 2022
- Subject
- Components, Circuits, Devices and Systems
Computing and Processing
Engineered Materials, Dielectrics and Plasmas
Fields, Waves and Electromagnetics
Photonics and Electrooptics
Electromagnetic heating
Protocols
Chemistry
Response surface methodology
Optimization
microwave heating
optimization
flow reaction
in-line analysis
response surfaces
- Language
The optimization of single-mode microwave-assisted flow reaction conditions was investigated by improving sampling efficiency through microwave power gradients and in-line analysis, and advanced prediction through response surfaces. Application to kg-scale organic transformations highlights the utility of this protocol.