Developing ultra-low-power devices requires low-power components, algorithms, and communication protocols. For environmental monitoring along the supply chain, products may travel a long way from the distributor to the customer. In addition, extreme climatic circumstances, such as temperatures below 0°C, affect battery capacity. In order to monitor package’s environment, it is crucial to ensure that all embedded system parts use as little energy as possible. This paper addresses how much power the SPI and I2C communication protocols use. These protocols are widely used in low-power embedded devices for sensor communication. Based on its results, this research article presented recommendations for developing ultra-low power embedded devices that use the SPI/I2C protocol.