Scientific and clinical research have advanced the ability of healthcare professionals to more precisely define diseases and classify patients into different groups based on their likelihood of responding to a given treatment, and on their future risks. However, a significant gap remains between the delivery of stratified healthcare and personalization. The latter implies solutions that seek to treat each citizen as a truly unique individual, as opposed to a member of a group with whom they share common risks or health-related characteristics. Personalisation also implies an approach that takes into account personal characteristics and conditions of individuals. This paper investigates how these desirable attributes can be developed and introduces a holistic environment, the iHELP, that incorporates big data management and Artificial Intelligence (AI) approaches to enable the realization of data-driven pathways where awareness, care and decision support is provided based on person-centric early risk prediction, prevention and intervention measures.