Dynamic Ventilation $^3$He MRI for the Quantification of Disease in the Rat Lung
- Resource Type
- Periodical
- Authors
- Kyriazis, A.; Rodriguez, I.; Nin, N.; Izquierdo-Garcia, J. L.; Lorente, J. A.; Perez-Sanchez, J. M.; Pesic, J.; Olsson, L. E.; Ruiz-Cabello, J.
- Source
- IEEE Transactions on Biomedical Engineering IEEE Trans. Biomed. Eng. Biomedical Engineering, IEEE Transactions on. 59(3):777-786 Mar, 2012
- Subject
- Bioengineering
Computing and Processing
Components, Circuits, Devices and Systems
Communication, Networking and Broadcast Technologies
Lungs
Magnetic resonance imaging
Rats
Ventilation
Biomedical imaging
Equations
Elastase-treated rats
%24^3%24<%2Ftex><%2Fformula>He+MRI%22">hyperpolarized $^3$He MRI
inflation rate
pulmonary ventilation
regional flow
- Language
- ISSN
- 0018-9294
1558-2531
Pulmonary diseases are known to be largely inhomogeneous. To evaluate such inhomogeneities, we are testing an image-based method to measure gas flow in the lung regionally. Dynamic, spin-density-weighted hyperpolarized $^3$He MR images performed during slow inhalation of this gas were analyzed to quantify regional inflation rate. This parameter was measured in regions of interest (ROIs) that were defined by a rectangular grid that covered the entire rat lung and grew dynamically with it during its inflation. We used regional inflation rate to quantify elastase-induced emphysema and to differentiate healthy ( n = 8) from elastase-treated ( n = 9) rat lungs as well as healthy from elastase-treated areas of one rat unilaterally treated with elastase in the left lung. Emphysema was also assessed by gold standard morphological and well-established hyperpolarized $^3$He MRI diffusion measurements. Mean values of regional inflation rates were significantly different for healthy and elastase-treated animals and correlated well with the apparent diffusion coefficient of $^3$He and morphological measurements. The image-based biomarker inflation rate may be useful for the assessment of regional lung ventilation.