Vegetation optical depth (VOD) depends on the water, structure, and biomass of vegetation. Here, we propose a multi-sensor approach to isolate the water component from the VOD and to retrieve gravimetric vegetation moisture (m g ) in the western United States. The approach estimates VOD from radar and LiDAR data and minimizes the differences between these estimates and SMAP/AMSR2 VOD observations. This minimization allows to obtain the best fitting value of m g with help of a dielectric model. Results are consistent both in space (drier vegetation in arid areas) and time (drier vegetation in drier months). The mg estimates are in the same range than in situ mg data, with some underestimation (bias ~ -0.07 kg/kg). Statistical results are reasonable (r ~ 0.45, RMSE ≤0.10 kg/kg), yet the different spatial and temporal representation of in situ and remote measurements have an impact in the direct comparisons. Our results highlight the potential for developing new vegetation moisture datasets based on VOD decomposition.