China manned space engineering has made many breakthroughs in manned space area and successfully completed the construction of China space station. During the operation of the space station in orbit, tasks such as rendezvous and docking, astronaut extravehicular activity, cargo extravehicular deployment and recovery, astronaut living and work, and scientific experiments are executed. In this paper, the requirements of management of China space station, the design of the space-integrated-ground network, and the execution of the space mission based on space-ground cooperation are described.