In order to solve the problem of data loss between image frames in optical camera communication (OCC), this paper proposes a synchronization method. While considering the performance differences of different cameras, this method achieves no data loss communication between image frames in the OCC system with high information transmission rate and strong compatibility by designing the communication protocol, automatically adjusting the receiving time and processing time of cameras, and specifying relevant parameters. Meanwhile, this paper has tested the parameters that influence the OCC system and verified the feasibility of the synchronization method through the establishment of the OCC system.