Numerical and experimental methods are used to understand the impact of trajectory variations on the active implantable medical device (AIMD) models, i.e., the transfer functions, used for RF-induced heating safety evaluation. The transfer function (TF) models are developed along various trajectories via numerical modeling and experimental measurements. Based on the trajectory used in this study, it was observed that the trajectory has little effect on TF. Consequently, the TF can be used to evaluate the RF-induced heating for various implantation trajectories inside human body models.