The control of economic activities by governments for the purpose of minimizing COVID-19 spread influenced atmospheric conditions. Satellite-based technology is promising to monitor these changes and even non-specialists in geospatial analysis can use it through cloud-based open platforms. This study aims to give scientific interpretation on the causes of the atmospheric changes based on these governmental controls on human activity. The nitrogen dioxide (NO 2 ) levels were monitored in Ayutthaya Province in Thailand in an urban area including industrial zones during January 1 to April 30, 2020. An analysis was conducted with Google Earth Engine by using four datasets including NO 2 data from Sentinel-5P. The mean value of NO 2 density in 2020 decreased 12.5% compared with that in 2019. The closure of industrial facilities by the government seemed to be a key cause of the phenomena. The decline was statistically tested and resulted in a significant difference between the two periods. As the new daily cases decreased to single digits, the difference became non-significant from May 1, 2020. Single timeseries analysis on NO 2 density change enabled visualization of the brief impact of responses and policies made by the government and subsequent economic activities; however, further atmospheric and industrial activity data are required for further assessment.