Computational Modeling of an Endovascular Peripheral Nerve Interface
- Resource Type
- Conference
- Authors
- Liu, JingYang; Grayden, David B.; Keast, Janet R.; John, Sam E.
- Source
- 2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC) Engineering in Medicine & Biology Society (EMBC), 2021 43rd Annual International Conference of the IEEE. :5966-5969 Nov, 2021
- Subject
- Bioengineering
Electrodes
Peripheral nervous system
Encapsulation
Electric potential
Computational modeling
Simulation
Blood vessels
- Language
- ISSN
- 2694-0604
Implantable neuromodulation devices that interface with the peripheral nervous system are a promising approach to restore functions lost to nerve damage. Existing nerve stimulation electrodes require direct contact with the target nerve and are associated with mechanical nerve damage and fibrous tissue encapsulation. Endovascularly delivered electrode arrays may provide a less invasive solution. Using a hybrid tissue conductor-neuron model and computational simulations, this study demonstrates the feasibility of delivering electrical stimulation of a peripheral nerve from a blood vessel in the vicinity of the target and predicts that the stimulation intensity required strongly depends on nerve-vessel distance and relative orientation, which are important factors to consider when screening candidate blood vessels for electrode implantation.