To ensure the extreme performances of the new 6G services, applications will be deployed at deep edge, resulting in a serious challenge of distributed application addressing. This paper traces back the latest development of mobile network application addressing, analyzes two novel addressing methods in carrier network, and puts forward a 6G endogenous application addressing scheme by integrating some of their essence into the 6G network architecture, combining the new 6G capabilities of computing & network convergence, endogenous intelligence, and communication-sensing integration. This paper further illustrates how that the proposed method works in 6G networks and gives preliminary experimental verification.