At this stage, college Spanish teaching has gradually shifted from the traditional theoretical and practical teaching methods to the teaching methods based on sports technology. In view of this, in this paper, the application situation of computer assisted translation technique in Spanish-Chinese interpretation was studied and analyzed. First of all, the status of computer aided translation technology and its application in the interpretation as well as related researches and theories were briefly introduced; the application process and evaluation algorithms of interpretation quality were detailed; with interpreters in an institution as the research sample, the corpus and interpretation quality were compared and evaluated; finally, the conclusion that interpreters need to coordinate the relationship between computer aided translation results and contexts was obtained, thus ensuring the accuracy of interpretation.