Virtual reality (VR) has become as a valuable tool in medicine and healthcare, benefiting physical and psychological treatments.The aim of this thesis is to address the specific needs of Spinal Cord Injury (SCI) patients by developing a VR cloud-based platform for upper limb rehabilitation. The research focuses on enabling patients to interact with an immersive virtual environment using their own hands, eliminating the need for external devices. To achieve this, the platform incorporates hand-tracking functions and ensures accurate recognition of functional grasps, allowing the patient to perform the activities necessary to improve dexterity and motor skills. By monitoring exercises and analyzing kinematic data, therapists and specialists can objectively assess progress and adjust treatment plans to optimize the rehabilitation process. The cloud-based approach allows remote access, data monitoring, and information sharing among healthcare professionals, enhancing treatment decision-making and optimizing outcomes for SCI patients. Finally, clinical trials will be conducted at the Hospital Nacional de Parapléjicos de Toledo (HNPT), a specialized SCI center. The objective is to carry out a functional and usability study of the developed platform, evaluating the physical impact and emotional well-being of the serious games implemented on the platform.