To solve the energy optimization scheduling problem of regional integrated energy system, the distributed generation output characteristics and the system optimization operation strategy are analyzed. Constraints of the distributed energy operation, electric-heat-cold load demand and the energy daily storage balance are fully considered. Then the optimal scheduling model of integrated energy microgrid is established and solved by linear programming method. Finally, a typical scenario is constructed referring a university campus, the CCHP optimal operation mode is carried out and compared with the operation mode of "CCHP full power". The results show that the optimal scheduling model can meet the scenario requirements, and can provide a unified optimization scheme for regional integrated energy system.