This study aims to assess the prefrontal functional connectivity using wavelet coherence analysis of cerebral tissue oxyhaemoglobin concentrations (Delta [HbO2]) signals in subjects with cerebral infarction(CI) during the resting state. Continuous recordings of near-infrared spectroscopy (NIRS) signals were gained from the right and left prefrontal lobe in 15 elderly subjects with CI (age: 75.1 ± 9.2 years) and 18 healthy elderly subjects (age: 69.9 ± 7.3 years) during the resting state. The coherence between right and left prefrontal lobe Delta [HbO2] oscillations in 4 frequency intervals (I, 0.6–2 Hz; II, 0.145–0.6 Hz; III, 0.052–0.145 Hz; IV, 0.021–0.052 Hz) was analyzed by the wavelet coherence analysis. In healthy subjects, the Delta [HbO2] were significantly wavelet coherent in interval I (0.6–2 Hz) and III (0.052–0.145 Hz) (p