Customized modular multichannel electronics for ultrasound-mediated targeted drug delivery with a geodesic piezocrystal phased array
- Resource Type
- Conference
- Authors
- Qiu, Zhen; Habeshaw, Roderick; Cochran, Sandy; Lines, Dave
- Source
- 2014 IEEE International Ultrasonics Symposium Ultrasonics Symposium (IUS), 2014 IEEE International. :811-814 Sep, 2014
- Subject
- Aerospace
Bioengineering
Communication, Networking and Broadcast Technologies
Components, Circuits, Devices and Systems
Computing and Processing
Engineered Materials, Dielectrics and Plasmas
Fields, Waves and Electromagnetics
Photonics and Electrooptics
Power, Energy and Industry Applications
Robotics and Control Systems
Signal Processing and Analysis
Arrays
Ultrasonic imaging
Temperature measurement
Transducers
Acoustics
Drugs
Heating
Multiple-channel electronics
NI-FlexRIO
NIPXIe
Array driving system
Piezocrystal
PMN-PT
Geodesic phased array transducer
Ultrasound-mediated targeted drug delivery
Therapuetic ultrasound
- Language
- ISSN
- 1051-0117
Ultrasound-mediated targeted drug delivery (UmTDD) has the potential to enhance the chemotherapeutic treatment of cancer by allowing increased drug doses preferentially at the location of the tumor. Although gaining increasing interest over the past few years, research into UmTDD system configurations has been hindered by the lack of experimental driving systems and ultrasound devices. In the work reported here, a piezocrystal composite geodesic phased array with 96 elements was connected to commercial programmable multi-channel electronics based on NI-PXIe / FlexRIO-FPGA hardware. The system was modified to provide appropriate ultrasound intensities through power and heat dissipation strategies. Auto-focusing was applied by phase aberration correction. Preliminary results using cross-correlation are presented to demonstrate its applicability. The pressure intensity at the focus of the array was increased four times while the intensity of side lobes were below −12 dB.