In recent years, Maasai Mara has paid more and more attention to the protection and utilization of wild animals and other resources. However, there is still a large room for improvement in the utilization of natural resources in Maasai Mara. Therefore, it is necessary to develop alternative specific policies and management strategies to achieve a balance between human interests and natural interests and reduce conflicts between humans and wildlife. This paper aims to build a model to introduce specific policies and management strategies to help better balance the relationship between human and ecology. The results of the model established indicate that population density, tourism GDP, and agricultural GDP are the three factors that have a significant impact on the evaluation of policy effectiveness while increase in the number of elephants and carnivores significantly increases the number of negative human-animal interactions.. Additionally, the establishment of the reserve has a notable effect on biodiversity conservation. Under the guidance of the best policy, in 2027, the GDP of the tourism industry in the Masai Mara National Reserve will reach 7.6606 billion US dollars in the first quarter.