The 2020 Covid-19 pandemic caused a sudden and massive change in work organizations. One of the major consequences of the crisis was the acceleration towards teleworking, through the specific phenomenon of Mandatory Work From Home: the situations in which workers overnight found themselves to work seven days a week from their home environment, constantly online, often without adequate equipment and little to no preparation. Different workers reacted in different way to this important change, depending on age, gender, family characteristics and other impacting factors. Mandatory work from home and these other variables impacted employees’ physical and mental health, triggering or increasing symptoms of overwork and emotional exhaustion among others. This paper contributes to the literature on the impact of the pandemic on workers’ health by giving an overview of the effects of MWFH on university staff, using Politecnico di Torino as a case study.