Influence of Transcranial Electrical Stimulation (TES) waveforms on neural excitability of a realistic axon: a simulation study
- Resource Type
- Conference
- Authors
- Sahu, Sulagna; Chauhan, Munish; Sajib, Saurav Z. K.; Sadleir, Rosalind J.
- Source
- 2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC) Engineering in Medicine & Biology Society (EMBC), 2021 43rd Annual International Conference of the IEEE. :6725-6727 Nov, 2021
- Subject
- Bioengineering
Axons
Computational modeling
Biological system modeling
Neural activity
Electrical stimulation
Tools
Brain modeling
- Language
- ISSN
- 2694-0604
Neuromodulation caused by transcranial electrical stimulation (TES) has been used successfully to treat various neuro-degenerative diseases. Simulation models provide an essential tool to study brain and nerve stimulation. Simulation models of TES provide an opportunity to research personalization of therapy without extensive animal and human testing. A computer model of a realistic sensory axon was built by finding actual geometry of the trigeminal nerve through tractography. A finite element model of the head was solved to obtain electric potential distribution caused by TES. Different waveforms were defined to test transcranial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS) with varying amplitude and frequency. Neural activity patterns were observed. The strength-duration curve was plotted to verify the model.