Chitosan-coated gold nanocomposites loading with cisplatin for potential use in cancer therapy
- Resource Type
- Conference
- Authors
- Preda, Petruta; Adiaconita, Bianca; Craciun, Gabriel; Mihalache, Iuliana; Boldeiu, Adina; Brincoveanu, Oana; Maxim, Monica-Elisabeta; Chiriac, Eugen; Avram, Marioara
- Source
- 2022 International Semiconductor Conference (CAS) Semiconductor Conference (CAS), 2022 International. :227-230 Oct, 2022
- Subject
- Components, Circuits, Devices and Systems
Engineered Materials, Dielectrics and Plasmas
Photonics and Electrooptics
Drugs
Nanoparticles
Gold
Spectroscopy
Nanocomposites
Loading
Medical treatment
nanoparticles
natural polymer
antitumor drugs
- Language
- ISSN
- 2377-0678
This paper discusses the synthesis of nanocomposites based on chitosan-coated gold nanoparticles (CS-AuNPs) and the loading with cisplatin drug (CisPt). Limited studies were performed on the evaluation of AuNPs functionalized with biopolymers and conjugated with CisPt. The loading of the CS-AuNPs with cisplatin was performed in order to obtain drugs delivery systems for cancer therapy. The obtained CS-AuNPs proved to be stable, with a slight agglomeration tendency (PI of 0.302) and a hydrodynamic diameter of 85 nm. The CisPt loading in the nanocomposites was confirmed by UV-vis spectroscopy.