The key objective of our research is to develop an implant model for humerus bone from the perspective of rehabilitation engineering. To order for the artificial implant to be perfectly compatible with the human body, the humerus prosthetics must be constructed in a manner consistent with the skeletal system. Several methods are available in order to comprehend mechanical properties of the humerus. But out of all techniques, vibrational and structural analysis is most recommended as it is easily comparable with a real-life model as well as non- destructive. In this study structural analysis (total deformation, strain, stress evaluation) has been performed considering humerus as anisotropic material consists of two different bone types: cortical and trabecular & then compared with prosthetic models designed using 3 different materials: titanium alloy, cobalt-chromium alloy & aluminium alloy in hand static condition and it was found that the best result on titanium alloy. Vibrational analysis has been done for evaluating dynamic response of humerus in different frequencies & compared with the frequencies of the titanium alloy based humerus prosthetic. The comparative properties of this analysis will be helpful for humerus implant design.