The blood-oxygenation-level-dependent (BOLD) signal, measured with the Magnetic Resonance Imaging (MRI), is currently used to detect the activation of brain regions with a stimulus application, e.g., visual or auditive. In a block design approach, the stimuli (called paradigm in the ƒMRI scope) are designed to detect activated and non activated brain regions with maximized certainty. However, corrupting noise in MRI volumes acquisition, patient motion and the normal brain activity interference makes this detection a difficult task.