The role of peroxisome proliferator-activated receptor in the treatment of non-alcoholic fatty liver disease
- Resource Type
- article
- Authors
- Sun Xin; Zhang Yan; Xie Meilin
- Source
- Acta Pharmaceutica, Vol 67, Iss 1, Pp 1-13 (2017)
- Subject
- non alcoholic fatty liver disease
peroxisome proliferator activated receptors
agonists
insulin resistance
inflammation
Pharmaceutical industry
HD9665-9675
- Language
- English
- ISSN
- 1846-9558
Non-alcoholic fatty liver disease (NAFLD) has been defined as a spectrum of histological abnormalities and is characterized by significant and excessive accumulation of triglycerides in the hepatocytes in patients without alcohol consumption or other diseases. Current studies are targeting new molecular mechanisms that underlie NAFLD and associated metabolic disorders. Many therapeutic targets have been found and used in clinical studies. Peroxisome proliferator-activated receptors (PPARs) are among the potential targets and have been demonstrated to exert a pivotal role in modulation of NAFLD. Many drugs developed so far are targeted at PPARs. Thus, the aim of this paper is to summarize the roles of PPARs in the treatment of NAFLD.