Interactive association of lipopolysaccharide and free fatty acid with the prevalence of type 2 diabetes: A community‐based cross‐sectional study
- Resource Type
- article
- Authors
- Xiuji Huang; Dan Yan; Mingtong Xu; Feng Li; Meng Ren; Jin Zhang; Muchao Wu
- Source
- Journal of Diabetes Investigation, Vol 10, Iss 6, Pp 1438-1446 (2019)
- Subject
- Free fatty acid
Lipopolysaccharide
Type 2 diabetes
Diseases of the endocrine glands. Clinical endocrinology
RC648-665
- Language
- English
- ISSN
- 2040-1124
2040-1116
Abstract Aims/Introduction Increased blood lipopolysaccharide (LPS) or free fatty acid (FFA) levels correlate with an increased risk of type 2 diabetes. The purpose of the present study was to evaluate the interactive effect of serum LPS and FFA levels on the prevalence of type 2 diabetes. Materials and Methods This cross‐sectional study included 2,553 community‐dwelling Chinese adults. Fasting serum LPS levels were determined using the Limulus Amebocyte Lysate Chromogenic Endpoint assay, and FFA levels were determined using an enzymatic method. The participants were divided into three groups according to the tertiles of LPS or FFA levels or nine groups according to the tertiles of LPS and FFA levels. The odd ratios (ORs) for type 2 diabetes were estimated using logistic regression analysis. Results We found that higher serum LPS or FFA levels were associated with higher high‐sensitivity C‐reactive protein levels (P